Galectin-4-mediated transcytosis of transferrin receptor
نویسندگان
چکیده
منابع مشابه
Galectin-4-mediated transcytosis of transferrin receptor.
Some native epithelia, for example, retinal pigment epithelium (RPE) and kidney proximal tubule (KPT), constitutively lack the basolateral sorting adaptor AP-1B; this results in many basolateral plasma membrane proteins being repositioned to the apical domain, where they perform essential functions for their host organs. We recently reported the underlying apical polarity reversal mechanism: in...
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Receptor-mediated transcytosis across the blood-brain barrier (BBB) may be a useful way to transport therapeutics into the brain. Here we report that transferrin (Tf)-containing gold nanoparticles can reach the brain parenchyma from systemic administration in mice through a receptor-mediated transcytosis pathway. This transport is aided by tuning the nanoparticle avidity to Tf receptor (TfR), w...
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At 4°C transferrin bound to receptors on the reticulocyte plasma membrane, and at 37°C receptor-mediated endocytosis of transferrin occurred. Uptake at 37°C exceeded binding at 4°C by 2.5-fold and saturated after 20-30 min. During uptake at 37°C, bound transferrin was internalized into a trypsin-resistant space. Trypsinization at 4°C destroyed surface receptors, but with subsequent incubation a...
متن کاملReceptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
At 4 degrees C transferrin bound to receptors on the reticulocyte plasma membrane, and at 37 degrees C receptor-mediated endocytosis of transferrin occurred. Uptake at 37 degrees C exceeded binding at 4 degrees C by 2.5-fold and saturated after 20-30 min. During uptake at 37 degrees C, bound transferrin was internalized into a trypsin-resistant space. Trypsinization at 4 degrees C destroyed sur...
متن کاملDendroaxonal transcytosis of transferrin in cultured hippocampal and sympathetic neurons.
Previous studies using overexpressed polymeric immunoglobulin receptor in cultured neurons have suggested that these cells may use a dendroaxonal transcytotic pathway (Ikonen et al., 1993; de Hoop et al., 1995). By using a combination of semiquantitative light microscopy, video microscopy, and a biochemical assay, we show that this pathway is used by the endogenous ligand transferrin (Tf) and i...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2014
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.153437